The two major urinary metabolites of cocaine are benzoylecgonine (BE) and ecgonine methyl ester (EME). The major advantage of BE screening is that many commercial immunoassays are designed to detect BE. On the other hand, EME is more amenable to gas chromatographic screening.

A rapid, rugged, and highly specific assay for the quantitation of cocaine (COC) and especially its primary metabolites benzoylecgonine (BZE) and ecgonine methyl ester (EME) in human urine has

Semantic Scholar uses AI to extract papers important to this topic. 2016. A rapid, rugged, and highly specific assay for the quantitation of cocaine (COC) and especially its primary metabolites benzoylecgonine (BZE) and ecgonine methyl ester (EME) in human urine has Analysis of cocaine, benzoylecgonine, ecogonine methyl ester, and ecgonine by high-pressure liquid chromatography-API mass spectrometry and application to a short-term degradation study of cocaine in plasma. This work describes a fast and fully validated procedure for the simultaneous detection and quantification of ecgonine, ecgonine‐methyl‐ester, benzoylecgonine, nor‐benzoylecgonine, m‐hydroxybenzoylecgonine, cocaethylene, cocaine, norcocaine and norcocaethylene in human urine (500 μL) using one SPE and simple derivatization. Ecgonine methyl ester is the O-debenzoyl analogue of cocaine.

This is a comment on "Sensitive, selective, and rapid procedure for the quantitation of ecgonine methyl ester in urine." J Anal Toxicol. 1991 Nov-Dec;15(6):345. ecgonine methyl ester, then to ecgonine (Ambre et al. 1988). About 1 to 5 percent of a cocaine dose is excreted unchanged in urine. Cocaine is rapidly cleared from plasma, but variably, at 20 to 30 mL/min/kg.

All 15 compounds were extracted from 3 mL of blood or urine by solid‐phase extraction and identified by a GC‐MS method. The overall recoveries were 49% for methyl ecgonine, 35% for ethyl ecgonine, 29% for ecgonine and more than 83% for all other drugs. Abstract The presence of ecgonine in urine has been proposed as an appropriate marker of cocaine use.

Long-term stability of ecgonine methyl ester in urine. Vasiliades J. Erratum in J Anal Toxicol 1993 Oct;17(6):9. Comment on J Anal Toxicol. 1991 Nov-Dec;15(6):345. PMID: 8371560 [PubMed - indexed for MEDLINE] Publication Types: Comment; Letter; MeSH Terms. Cocaine/analogs & derivatives* Cocaine/urine; Cold Temperature; Drug Stability; Humans

Benzoylecgonine and ecgonine methyl ester did not produce toxic manifestations at infusion rates that produced toxicity in the cocaine, norcocaine, and cocaethylene groups. Furthermore, 30- and 60-fold higher doses of benzoylecgonine and ecgonine methyl ester, respectively, were necessary to produce only mild neurobehavioral changes. Ecgonine methyl ester solution 100 μg/mL in acetonitrile, ampule of 1 mL, Ecgonine methyl ester is a major urinary metabolite of cocaine, a popular illicit drug of their metabolites, and anhydroecgonine methyl ester, a pyrolysisproduct, in liva, and urine according to the biologicalfluid and time of measurement. 1 Jun 1997 Ecgonine Methyl Ester, a Major Cocaine Metabolite, Causes Cerebral EME and BE have been detected in urine and/or plasma after cocaine Ecgonine methyl ester is a major urinary metabolite of cocaine, a popular illicit drug applications in urine drug testing, clinical toxicology or forensic analysis.

1988-01-01

Cocaine is rapidly cleared from plasma, but variably, at 20 to 30 mL/min/kg. Elimination half-life of cocaine is similarly variable, Froldi R., Gambaro V., Groppi A. (1987) Cocaine, Benzoylecgonine and Ecgonine Methyl Ester Determinations in Post Mortem Human Urine and Blood by Gas Chromatography and Capillary Gas Chromatography after “Extrelut®” Extraction. zoylecgonine (BZE) and ecgonine methyl ester (EME). Both compounds remain detectable 4-6 times longer than COC in urine and plasma. Studying the causative factors, which alter the pharmacological and toxicological effects of COC, is of sig- nificant clinical importance. A sensitive and specific bioanalyt- "Confirmation and Quantitation of Cocaine, Bezoylecgonine, Ecgonine Methyl Ester in Human Urine by GC/MS." Journal of Analytical Technology Vol.12 (1988): 153-55.

J. Anal.

The major advantage of BE screening is that many commercial immunoassays are designed to detect BE. On the other hand, EME is more amenable to gas chromatographic screening. To ascertain the merits … In this study, 25 postmortem urine specimens testing positive, for cocaine and ecogonine methyl ester (EME) by full scan electron impact gas chromatography/mass spectrometry, were used to evaluate the stability of EME in refrigerated and frozen conditions. Long-term stability of ecgonine methyl ester in urine.
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1984-01-01

After an initial quantitation (t = 0), these specimens were split and stored at either 4 Long-term stability of ecgonine methyl ester in urine. Vasiliades J. Erratum in J Anal Toxicol 1993 Oct;17(6):9. Comment on J Anal Toxicol. 1991 Nov-Dec;15(6):345.

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Ecgonine methyl ester had an elimination halflife of 4.2 hr, compared with 5.1 hr for Rapid confirmation/quantitation of ecgonine methyl ester, benzoylecgonine, and cocaine in urine using on-line extraction coupled with fast HPLC and tandem 1 Nov 1977 Benzoylecgonine and Ecgonine Methyl Ester Concentrations in Urine Specimens . Journal of Forensic Sciences 1995, 40 (1) , 13769J. Benzoylecgonine is the main metabolite of cocaine, formed by the liver and excreted in the urine. It is the compound tested for in most cocaine urine drug screens. Chemically, benzoylecgonine is the benzoate ester of ecgonine. It is a metabolites, such as ecgonine methyl ester ( EME) and benzoylecgonine ( BE), in urine and blood, are presented; a fatal cocaine poisoning case, which the of cocaine and its metabolites (benzoylecgonine and ecgonine methyl ester) in huma OF COCAINE AND ITS METABOLITES IN BLOOD AND URINE.